| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Paris Saint-Germain | 10 | 9 | 0 | 1 | 24 | 10 | +14 | 27 |
| 2 | Lens | 10 | 5 | 3 | 2 | 16 | 11 | +5 | 18 |
| 3 | Marseille | 9 | 5 | 2 | 2 | 18 | 11 | +7 | 17 |
| 4 | OGC Nice | 9 | 5 | 2 | 2 | 17 | 5 | +12 | 16 |
| 5 | Angers | 10 | 4 | 4 | 2 | 15 | 11 | +4 | 16 |
| 6 | Lyon | 10 | 4 | 4 | 2 | 16 | 13 | +3 | 16 |
| 7 | Stade Rennais FC | 10 | 4 | 3 | 3 | 15 | 9 | +6 | 15 |
| 8 | Strasbourg | 10 | 4 | 2 | 4 | 18 | 15 | +3 | 14 |
| 9 | Nantes | 10 | 4 | 2 | 4 | 14 | 11 | +3 | 14 |
| 10 | Monaco | 10 | 4 | 2 | 4 | 14 | 13 | +1 | 14 |
| 11 | LOSC Lille Métropole | 10 | 4 | 2 | 4 | 13 | 15 | -2 | 14 |
| 12 | Lorient | 10 | 3 | 5 | 2 | 11 | 13 | -2 | 14 |
| 13 | Montpellier Hérault SC | 10 | 3 | 4 | 3 | 17 | 16 | +1 | 13 |
| 14 | Clermont | 10 | 3 | 4 | 3 | 13 | 20 | -7 | 13 |
| 15 | Stade de Reims | 10 | 2 | 5 | 3 | 11 | 12 | -1 | 11 |
| 16 | ESTAC | 10 | 2 | 3 | 5 | 9 | 14 | -5 | 9 |
| 17 | Girondins de Bordeaux | 10 | 1 | 5 | 4 | 12 | 21 | -9 | 8 |
| 18 | Metz | 10 | 1 | 3 | 6 | 11 | 22 | -11 | 6 |
| 19 | Brest | 10 | 0 | 5 | 5 | 11 | 19 | -8 | 5 |
| 20 | Saint-Etienne | 10 | 0 | 4 | 6 | 9 | 23 | -14 | 4 |
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| Monday, October 18, 2021 | ||
| Marseille | 4 - 1 | Lorient |
| Sunday, October 17, 2021 | ||
| Montpellier Hérault SC | 1 - 0 | Lens |
| Strasbourg | 5 - 1 | Saint-Etienne |
| Metz | 0 - 3 | Stade Rennais FC |
| Brest | 1 - 1 | Stade de Reims |
| Girondins de Bordeaux | 1 - 1 | Nantes |
| ESTAC | 1 - 0 | OGC Nice |
| Lyon | 2 - 0 | Monaco |
| Saturday, October 16, 2021 | ||
| Clermont | 1 - 0 | LOSC Lille Métropole |
| Paris Saint-Germain | 2 - 1 | Angers |
| Monday, October 4, 2021 | ||
| Saint-Etienne | 1 - 1 | Lyon |
| Sunday, October 3, 2021 | ||
| LOSC Lille Métropole | 2 - 0 | Marseille |
| Nantes | 2 - 0 | ESTAC |
| Monaco | 3 - 0 | Girondins de Bordeaux |
| Lorient | 1 - 1 | Clermont |
| Angers | 3 - 2 | Metz |
| Stade Rennais FC | 2 - 0 | Paris Saint-Germain |
| OGC Nice | 2 - 1 | Brest |
| Saturday, October 2, 2021 | ||
| Montpellier Hérault SC | 1 - 1 | Strasbourg |
| Lens | 2 - 0 | Stade de Reims |
| Saturday, October 23, 2021 | ||
| Saint-Etienne | 00:30 | Angers |
| Nantes | 20:30 | Clermont |
| Sunday, October 24, 2021 | ||
| LOSC Lille Métropole | 00:30 | Brest |
| OGC Nice | 16:30 | Lyon |
| Lens | 18:30 | Metz |
| Lorient | 18:30 | Girondins de Bordeaux |
| Stade de Reims | 18:30 | ESTAC |
| Stade Rennais FC | 18:30 | Strasbourg |
| Monaco | 20:30 | Montpellier Hérault SC |
| Monday, October 25, 2021 | ||
| Marseille | 00:15 | Paris Saint-Germain |
| Thursday, October 28, 2021 | ||
| OGC Nice | 00:30 | Marseille |
| Saturday, October 30, 2021 | ||
| Paris Saint-Germain | 00:30 | LOSC Lille Métropole |
| Metz | 20:30 | Saint-Etienne |
| Sunday, October 31, 2021 | ||
| Lyon | 00:30 | Lens |
- The top three teams in Ligue 1 qualify for the Champions League, with the top two proceeding directly to the group phase.
- The third-placed team enters in the third qualifying round. The fourth-placed team qualifies for the UEFA Europa League.
- The other two Europa League places are determined through the country’s two domestic cup competitions, the Coupe de France and Coupe de la Ligue.
- If both of the cup winners qualify for Europe through their league position, the fifth- and sixth-placed teams in Ligue 1 will qualify for the Europa League.